CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
SMO	6608	Smoothened homolog (Drosophila)	7	Gx; SMOH; FZD11

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
17683069	2007	Cell line : Colo 320, HCT 116, Smo, Colo 205, HT 29 and WiDr,Colo 205, Colo 320, Caco 2, SW 480,293 T Source : ATCC Sample Type : - No. of Sample : - Stage : -	RT-PCR, Western blotting , Transfection experiments.	Down-regulation	-	-
15072830	2004	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	-	Methylation	-	Expression of wild-type SMO is required for expression of GLI3 by a mechanism that is independent of conventional Hedgehog signalling.
21438024	2011	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 77 CRC patient Stage : -	Promoter microarrays, real time RT-PCR, Methylation Specific PCR	Methylation	-	The frequency of their promoter methylation was assessed in the larger group of patients (n = 77): KCNK12, GPR101, BARX1, CNTFR , SYT6, SMO (21%), EPHA5, and GSPT2.
22901214	2012	Cell line : - Source : Department of Gastroenterological Surgery of this hospital. Sample Type : CRC tumor and normal tissue No. of Sample : 43 cancer tissue and adjascent tissue sample Stage : -	real time RT-PCR, Immunohistochemistry	Up-regulation	-	Positive rates and intensities of mRNA and protein expression of Hh signaling pathway related genes SHH, SMO, GLI1 were found to be significantly increased in CRC tissues.

Gene Details

Chromosome: 7; NC_000007.13 (128828713..128853386)
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Gene Type	protein coding
Gene Family	GPCR / Class F : Frizzled receptors
Description	The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]
Chromosome	7
Location	7q32.3
Start	129188872
End	129213546
Strand	+
Gene Sequence	>gi\|568815591:129188872-129213546 Homo sapiens chromosome 7, GRCh38.p2 Primary Assembly GGGCTGAAGACAACTTGGATTGCGAGGCTAGGGCTTGGGGAGTCGTGCATCCCGTTCCGGGCCTCCGCAG CCCAACATGGGCCCCGGGTTCCAAAGTTTGCGAAGTTGGGCGCCGAGGGGCCGGGGCGCGCGGAGCGTCC GGGGGGGCCCGGGCCCGGATTCTCTGGGCGCACAGGTCGCCTGAGCCGCCTCCGCGGCCGCCGAGGTCGT GCGTGTGGCCGGGGGGCTCCGAGGAGCAGGCGGGGGCGCCGGGGCTTTTGCTGAGTTGGCGGGGTTGGCC ATGGCCGCTGCCCGCCCAGCGCGGGGGCCGGAGCTCCCGCTCCTGGGGCTGCTGCTGCTGCTGCTGCTGG GGGACCCGGGCCGGGGGGCGGCCTCGAGCGGGAACGCGACCGGGCCTGGGCCTCGGAGCGCGGGCGGGAG CGCGAGGAGGAGCGCGGCGGTGACTGGCCCTCCGCCGCCGCTGAGCCACTGCGGCCGGGCTGCCCCCTGC GAGCCGCTGCGCTACAACGTGTGCCTGGGCTCGGTGCTGCCCTACGGGGCCACCTCCACACTGCTGGCCG GAGACTCGGACTCCCAGGAGGAAGCGCACGGCAAGCTCGTGCTCTGGTCGGGTAAGTGCGGCGGAGCCGG GTCTGGGGGGCGGGAGGTGCCGCGGTAAGATGGGGGCACCCTTGGAAAGAACAGGCTCAGGCCTGAGTTT TGGAGAGGGCGGGGACAGCACCCGGGAGAGTTGGAGGGACAGATCCCGAAACTTTGGGGGCAGGTTACGT GCAGGATGGGACCCTCGGTCATGGGAAAAGGAGGGCAAGGAAGTTGACGAAGCGGGTCACAAAGGGCCTG AGCTGGTGGGTGAGCAAAGGATGGCGGGGATGAGGGGCCCGTGAGGAGGTGGCTCTAAGCCACGGGAAAA GACATTTTGTAAGAAGAGGAGATGCTCCACCTATTCTGGAAGCAGGGTGCCGGGGGATTCAAGGAGGTGT TGAAGACCCTGGGGAAATTGGAGTTGGAGAGGAAAAGGGGAGGGATGACGGAGGAAGAGGTTTAGACATT TGGAGGGAAGGGTAGGGGGACATGATCGAGTGAAGTTTTGAAGGAAAAGAAACCTCCCTAGTGATGAATT ATTAAAAGGTAACCAGAAAGTTCTGGAAATCTTGATTTGGGAGACAGGAATGAAGCCTAGAGAACTGTGA TCTTGTCTGGCTTTCACGGGAGATTTCATTCAGTTTGTGCATCTGAAAAACCGGCCCTCTGACGCATGCA GGAGGTTATGAAGGAATAAGACCTTTCTAACAGTTATTTGTGTTTTCTTTGGAAATTTGGTTACCGAGGC TGGTCAGGGCTGTGGAAGGACGCTTAAGTCTGGAGTGTTGAGAGCCTGTGGACACTTCCATGGTGGTTTG AAGTCCCAAAGCCCCCTCACTGGAGTGGCAGAGTCTGAAAAACTGCACACTGAACCCAAATGTCCTTCCT TAGCAGTGTGGAGTATACTCTCCCCCACCTGTCACTTTTCTAGATGAGGCTTGGAGGGTGCTGAGGAAGG GAGCTGGCCTTATCAGCCCTCGCTTCTAGCCAGTATGATTCTAAAACTGTCCTGGGAAAAAGAAAAGAAA ACCAGGAGCCAGGAGCAGAACTGGGAGCCTCCCTCTTTTGACAGGGCTGGGGTACCCCATCTCTTAGCTC TGCCCAGGGGGCTGGTGAGGACCCTAATGTAGGGAGTGTATGTAGGCCGCCTGTCATTGACAAGTTCTCG GCCTTTGTCAGATGTTGGACAAGGCCATAAGGTTCCTGGCTTGGTGCAGATGCTGGAGGAGGAACTTGGA GGATGGTATCCATGGTACCCATGAGGAAGAGCTGCATCCTTTTTGGGGATCAGGTTCTAAAGTCAGCACA GCACATTAGACAGAAATCATGTGTAAACAACAGTGGCTTTGAAAACTCTGCAGATTACCATAGTGTAAGG TGGATGTGGTTTTGCATATACACTTCTTTTACGATGTTTGCATACATGTGTTACATGTATACTCATATAT AAGAATGGGTATACATAGAAGATAAAATAATTGTAATTTTAAAGTTACATTCATGCAAAAGACTGAAATA ATAATAATAATAATAAAAAGAACACCAAAGTGAGATTAAGCAAGATTGCTTTGAGCACCACCCAAAATGA GACTTGAGTTTAGGAGCCAGCTGTGTGGAAAGTCCAAATCTCTCAGCACTAGAATCTCACCCAGTTCTGA GTTGCTCATGCTGTCAGAGGATAATCTTTCTGTCCCTCTCTTTATTGATTGTGCAAGGACCCATGGTTTA ATTTTCCCAAGTTAAATGCATGTTTGATGTTGCCTCTGTGTAGTTACCATCAGATCAAGGAGGAAGGGTA TGAACCTCTTTCCAGCCCATACTCTTGAGAGCAGCTGCTGAGCAGACAGAAGTAGTTTAAGCTGGAACAT GTATCAATTAGTACCATCTGCAGGTTGTGCAGGTTGAAATCTCACTATCTGTGCCTTTTGGCAGGGCAGG GTCCTACAGAGATGCCAGCACTGAGCCCAGCACCGTTAGTTCCATTAGTTCACTATGAGTTCTTCTCTGC CACCAACCACCATCCCTCAGCTCATTCCTGTTTCCATATGTGTTCTGGTTGCACTCTTTCTGCTTGGGAC TTGCAAGTAGGGCAGAAGCAGGTGTTGGCTTGAGCTGGGTAATGAGTAGGTAGAGTGAACCCAAGCCTCG TGTGAGAATCACAGCCAGGTCAGCTGGTAGCCTCTGGCAAGTGATTTATCATGTCCCGAGTTAATGATCT TGATTTTGCATTAGACAGGGTCAGTGTTACCTGGCTCTTAGGGGTGTTTTTGTGGGTGAAGGATGAAGGT GATCTAGGTTGTCTTCATCGGTAAACTCTTGAATGTAGGAACTGGGTCTTCACTTTTTTTCAAAGCCTGT GAGTACTGAGTACACAGCCATGCTTCTATTCATGCATTCAGTTATGTATTGAATGTTTGCTGTATGTCAC ATGCTGCGCATGTAAGGATGAAGAATACAGATATGATCCTCTGTCATCAAGAAGACAGGCTGGACATGGT GCTCACACCTGTGATCTCAGCACTTTGGGAGGCCGAGGCGGGAAGATTGCTCAATACCAGGAGTTTAAGA CCAGCCTGAGACCTTGCCTCTAAAAAAAAAAAAGGAAGACAGATAATTCAACAGGCTTTGGAAATACCTG TGAAAGGTACTGTGGCATTTTAGGGTACTGAAAAAGCATAAAGGACCCAAGGAACATCCCAGAAGAACTG GCATTTAACCCATAACTTGACACATAAGCAGGAATTGCCTGGCCGAGGGAGAGTTGAGGTTTGAAGGGAT AGGAAGAGGAAATAGCATGTACAAAGGTGTAGAGGTAGGAGGGCTTGGTGCTTTGAAAGAAAGTATAAGA GTTGCAGTAGAACTGGATCAAAGCGTGTGAGGGGTGGAATTGTGAGAGATAAGACCTAAAGAATTAGAAA ATAAAGGGATTTATACCTCATATTAAGTTTGGATGTTATCCAGGGGATGATAAGGAGCCATTGAAAGATT TTAAGCAAGGGAGAGATGTAATTGTCTTTGCATTTTAGCTGGATCTCTTTGGGTATGGTGTGAAGAAGCC ATAGGAGCAGGGAAAGCCTGGAGCCTGGCTTCTTGACCAGGGGATGTTGAAGTAGCCCAAGTAAGAGACG ATGGCGGTTGGGACTGGGTAGCAGGACAGAGGGAGTGGGCAGATCCCACTAACTTTCAGAGGTAGTGCTC ATAGGGCACTGATGAGTTAGATGTGGAGCCTCAGTGAGCAGGAGGCCTCGGGTTTCAGGCTTGGATGGAA GGTGGTGCCATTCCCTTTCACTAAGATAGAGAATGCTAGAGGAAGAAGAAGTTTAGGCAGGAGGTGTGGC TTTGATTTTGGCCGTGTGAATTAGAGATGCTCATTGGACATCTATGTGGAGATTCTCAGCAGATCTGGAA ATAGGAATTGCTGGAGAGAGGTGGCCACTGTGTGCTTCCTTGGCCCTGACTACTGAGGCTTTGGAAGGAT GCCATTGACTGAGGAAGTTTATAGCTCAGGTTGGTCCAATTTCTAGGTCTGTATAGACCTCAGGTCTTTC CTCTGTCTTTCATCTCTCTGGCCTCAGGCTTCTTCAGTCACTTAGCATCTCTCCCCTTTACAGCTGGAAA TGCCTCCTCCCGGGCATTCCAAGCTGACCAGACAAACATAATGTCCAGGCCGTGGTCCACCTTAGGCCAA ACCTGGTTTAGTAAGTGGGGCAAAAAAGCAGAGAGGCCTGCAGCTGGCAGTGGCGATAGGTCCCTGAGAG CCAGCACGTAGCCTCCTTAACCACTGCTGTGCTCTGTGTGGTACATAAGTGTGTGGCCCTGTCACCTTGC CCACTTGCAGGTAAGTAGGAGAGAGACAAAGGCTGGGAGGAATTTCTTGTTTGCCTCTCACACATTGAAT TGAGGGCTGAGAGGAGGAATGTTTTTGGTGATGGTGGGTTATTTTCAGGGACGGATCAGGAAGAATTTCC TTAGAGCTATTTCCAAACTTGGCTGGTAATCAGAGTCAGTTAAAAAGATATATATGGCCGGGCGCGGTGG CTCACGCCTGCAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACGAGGTCAGGAGATCGAGACCA TCCCGGCAAACAGGGTGAAACCCCGTCTCTACTAAAAATACAAAAAAATTAGTTGGGCATGGTGGCGGGT GCCTGTAGTCCCAGCTGCTTGGGAGGCTGAGGCAGGAGAATGGCGGGAACCCGGGAGGCAGAGCTTGCAG TAAGCCGAGATCACGCCACTGCACTCCAGCCTGGGCGACAGACCGAGACTCCATCTCAAAAAAAAAAAAA AAAAAAAAAAAAAAATATATATATATATATATATATATATATATATGTATAGGCTGGGTGCAGTGGCTCA CACCTGTAATCTTAGCACTTTGGGAGGTTGAGGCAGGAGGATTTCTTGAAGCCAGGAGTTCGAGACCAGC CTGGGCAACAAAGTGAGACCCCATCTCTAAAAAAAAAAATTAGCCGGGCATGTTGGCACACACCTGTGGT CCCAGCTACACTGGAGGCTGAGGCAAAAGGATCGCTTGAACCCAAGAGGTTGAGGCTGCAGTGAGCCATC CTCACACCACTGCCCTCCAGACTGGGCAACAGAGCAAGACCCTGTCTCAAAAATACATACATACATATAG ATATGTGTGTATGTATACACACACACACATATATGTATAGTGAAAATGTAAAATACAGAAAAACATACAT GGACCTAAGTCTTTTTTAAAAAAAAATTATCTTTAATTAATTATTTGAGAAATGGGGTCTTGCTGTGTTG CCCAGGCTGGAGTGCAGTGGCTATTCAGAGGCTCACTCATTGTGCGCATGGTGCTTATGGTGCCTGGAAT AGCTGGCACTACAGGCATGTGTTCTGTGCCAGCTCAAGTCTTCAATTTTGCTTCAGATCTTTAACTTTTT AATTGTGAAATATAACTGTATGCAGAAAACTGCATAAAACACAAAGGTACTGAATAACAAATAATTATAA AGTGACATCTGGGTCAATAACTAGACCACAGTCAGACCCCTGAAGCTCCCTCTGTGTCTTGTCTAGTCAC ATCCCCCTCCCCTTGCTCAAGAGGTTTTCAGTAATCACATCCTTTTTTTCTCTATGGTTTTACCTCCTAG TTTTGGAATCCATAAGCAGTATATTTCAGCTTTGCATGTTTTTGAACTCTGTTCAAATGGAATTTGTACA AAATAATATGCTGTGCATATTATTTCTTGCTTCTTTTACTTTATATCATTATGTAAGATTCATCCATGTT ATTGCAGCTTATTTCTTTTTTGCTTGTTTATTTGTTTGTTTTTGTTTTTTTGAGACAGTCTCACTCTGTC ACCTAGGCTAGAGTGCAGTGGCGCGATCTCGGCTCACTACACCTCCACCTCCTGGGTTCAAACGATTCTC CTGCCTCCGCCTCCCAGGTAGCTGGGACCATAGGTGCACGCCACCAGGCCTGGCTAATTTTTGTATTTTT TAGTAGAGACAGGGTTTTGCCATGTTGGTCAGGCTGGCCTCAAACTCCTGACTTCAGGTGAGCCACCCGC CTCATACTGCAGCTTATTTCTTCATTGCTGAATAATATTCCATTATATGAGTATACCCCCAGTTGTTTAC CCATTTTATTGTCATCTCAAGTTTTTGCCCATTGCAAATAACATTGCTGTGAGTAGTCTTTTATGTATAT CCTAGTACAACTGGCACAAGTTCCTTCAGGTATATGCTGAAGAAGTAGAATTGCTAGATAATAAGGCACG CATACTTTAGGCTTTTGCCAAACCATTTTTCAAAGTGGTTGTACTAACTTATACTCCCACTAGCTAGTAG AAAGTCAACACTGGTTCACATGATTCCCAACATTTGGTATTATCAGCCTTTTACATTTTTGCCAATCTAG TGGCTATATTGTGGCATATATTTGTGGTTTTAATTTGCACTTCCCTGATTACTAGTAAAGTTAAATGCCT TTTTAAATGCTTACTGGCCTTTAGGGTTTCTGCTTTTGGGAAGTGTCTGTTCAAATCTTTGACATATTTT TCCATAGGGGCTATCTGTCATTTTTGTAAGATTTGTAGGAGTTCTTTATATATGCTAGATATGAGTTTAT AGGATTACAAAGGAAATCAATTATATTGACATAATAGTTATCAAATATAAAAATGCAAGTATGTGGGCTT ATTTATTTATACAATAAATAAGATCTGGTGCAGGTGTAATAACAACTATAATATCAAAGTGATTATAAGC ATTGACATTATTTCAAGATATCTGCAACAAAAATATCTGGTTTCCACTTGTGACAACGCCACAGGTACTA TTAACATTATGTACTGTGGGCCAGGCGTGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGTCAAGG TGGGCAGATCACGAGGTCAGGAAGTCGAGACCATCCTGGCTAACACGGTGAAACCCCATCTCTACTAAAA ATACAAAAAATTAGCCGGGCGCGGTGGTGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAA AATGGTGTGAACCCAGGAGGCGGAGCTTGCAGTGAGCCGAGATCGTGCCACTGCACTCCAGCCTGGGTGA CAGAGTGAGACTCCCTCTCAAAAAAAAAAAAAAGAAAAGAAAAAAAAAACAAAAAAAAATTATGTACTGC GATGTGTTGCTTACATTCATAATTGGAGGAAGGGCCAAATTTTAGTTAGGTGTAATTTTTTTCCCATTGA AATTCATGGACCTCTGAATTTTTCCAAGAATCCTTTGTGAACCATAGGGTAAGAATGTTACTTACAGAAT ATCACTATCTAGTAGAGAGTCTGAGCTATTCTTGATTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTTAA TAGAGACAGGGTTTGACCCTATTGTCCCGGCTGGTCTTGAACTCCTGGGCTCAAGTGATCCTCCTGCCTT GGCCTCCCAAAATGCTCCTTTGTGTTTTAATATAAAAATACTTGGTGATTTTTTATTGGGATTGCATTGA CTATATAGATTAACTTGGAAAAAAAAAGAGACATCTTTACAATACTGAGTCTTCCAAACATTGAACATTT ATATATTTCTATTTAGATCTTTCATTTTCTCAATATTCTGCACAGATTTAAATACTTATTATTTGTTAGA CATTCCTAGGTACTTGATATTTTTGATGCTGTTGTAAATGATGCCTTTAACATTTATTTCACTTTGTTTG TTGCTGACATATAGAAATAAAACTGGCTGGGCACGGTGGCTCACACCTGTAATCCCAGCACTTCGGGAGG CCAAGGCAGGGGGATCACGAGGTCAGGAGATTGAGACCGTCCTGGCTAACATGGTGAAACTCCATCTCTA CTAAAAATACAAAAAGTTAGTCGGGCATGGTGGCGGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGG CAGGAGAATGGCGTGAACCTGGGAGGCGGAGCTTGCAATGAGCCCAGATTGTGCCACTGCACTCCAGCCT GGGCAATACAGTGAGACACCGTCTCAAAAAAAAAAAAAAAAAAGAAATAAAATTGATGCCTTTAACATTT ATTTCACTTTGTTGCTGATATATAGAAATAAAATTGATTGTGAATTCAGTAAACTTGCTAAATTTATTCT ATACACATAGTCATATAATTTGTGAGTAATGAGTTTTGTTTCTTTCTTTCCAAGTCTTATACCTTTTATT TATCCTTATTGCTTTACTGAAGGCTTCCAGTACATTGTTAAATAGACAAAACATCTTAATTCTTGACTTT TCTGGATTCTAAAAAGAAAGCTTTTTCTACCCTTCACCATTAAATTTGATGTTTGGTATAGGTTTTTTAT AGTTAATTACATTTTATCAGATTAAGAACGTTGTCTCTTATTTCAAATTTGCCAATTATTCTTTTGATCA TAGATGGATGTTGAATTTTATCAACTTTTTTTTTTGGAGACGAAGTGTCACTGTCACCGAGGCTGGAGTG CAGTGATGCGATCTCAGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCC CAAGTATCTGGGACTACAGGCGCATGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGG TTTCACCGTGTTAGCCAGGTCAATTTCCTGACCGTGTGATCCGCCCGCCTCAGCCTCCCAAAGTGCTAGG ATTACAGGTGTGAGCCACTGCGCCCGGCTGAATTTTATCAACTTTTTTTTGCATCCATTGAGATGATCAT ATGATTTTTTTCTCCTTTAACCTGTTAATGTAGTAAATTGCATTGATTGAATTTTCTAATATTAAACCAG CCTTAGAACAGTGATACTCAACTTGACTAGTCATCAGAATCACACAAATAAAAAGTCTTTTTAAAAGTCT AGATCAGCCAGGCGCGGTAACACCCGTATTCCTGTTTCTCTTTTTGTTTCATATTTTATTAAAATAAAAG AAGTAAAATAATACTGATAAAGCTGATATCCCCTCTCTTTCTCGTTTCAGTTTCATATCCTTCTTTTCTC TTTGGAAAGCTTCCCCATCCTAGTAATTTGTGTATTTCTTTATTTTGTTTTTAAGCTCAAGTTTTGTTTT TGTTTTTGTTTTTGTTTTTTTGTAGAGATGGGGTTTGGCCATATTGCCCAGGTTGGTCTCGAACTCCTGA ACTTAAGTGATCCACCCACCTTGGGCCTCCCAAAATGCTAGGATTATAGGCGTGAGCCACCATGTCCAGC CTTAAGCTTAATTACTTTTAAAAAATAGGTTATACATGTACATGGCACAGAATTCAAAAGGAACAAGTTA AGTCCTACTTCTGCATCTAGCTACCCATTTTTCCTCTGCAGAAGTAACCACCAACACTGGTTTTTGTGTC CTTTTGGAAATATCCAACATCTGTCCAGATGTAGATGTGCTCTCAGTCTCTCCTCTACCGCCCAACCAGT ACCATGCTCTATAGACTGCTCTCCACTCAACTGAGTCCATGTAACATGACAACATTGGACATCATTCCAT TTCAATGCACATCCTGTCATGCACCCCAGAAGGAGATTTTGGTTAACAATGGACCACATGTGATGGTGTT CCCTTAAGATTATAATACCACATTTTTACTGTAGCCTTTCAATGTTTAGATATGTTTAGATACACTGATA CTCACCGTTGTGTTACAGTTGCCTGCAGTATTCAGTATAGCAACATGCTGTACAGGTTTGCAGCCTAGAA GCCATAGGTTATACTGTATCAGCTAGGTGTGCAGTAGGCTATACCATCCAGGTTTGTGTAAGTACACTCT GATGTTCACACAAAGATGACATTGCCTGATGACACATTTCACAGAAGATATCCTCATTGTTAAGCAACAT GTGACTATATCTCAACCCTGAATAGTGTTCTATTATAATGGTGTACATTATTTTACTTGGTTGGTCTCCT ATTGATGGATATGGATTCAAGCTGTTTCTACTTTTTTGCTATTGCAAAACAGTGCTGCAATGAATAATCT ATATTATCTTTGTGAACATGTGAAGTAGAAGTACTAGTATAAAATTTTGGTAGATAATGCCAAAGTGATC TCCACAAGTGTTTACTAATTTTTATTCCTACCAACAAATATAAAAGTGCCAGTTTATCCCTACACTCTTT ATAGTACGGTATTTTCTTTTCTTTTTTTTTTTTTTTTTGAGATAGAGTTTTGTTCTGTCACCCAGACTGG AGTGCAATGGCGATCTCGGCTCACTGCAACATCCGCCTCCTGGATTCAAGCAATTCTCCTGCCTCAGCCT CCCAAGAAGCTGGGATTACAGGCGCCCACCACCACACCTAGCTAATGTTTGTAGTTTTTTAGTAGAGACG GGTTTTCACCATGTTGGCCAGGCTTGTGTAGAACTCCTGACCTCAGGTGGTCCACCTGCCTCGGCCTCCC AAACTGTTGGGATTACAGGCGTGAGCCACCACCATGCTCAGCCTTCTTTATGTTTTTAAAGGCCATTAAA TGGCCTTGAGTCCAGGAGTTCAAGACCAGCCTGAGCAACATGGTGAAACCTTGTCTCTACAGAAAAATAC AAAAATTCACCAGGTGTGGTGGTGTGAGCCTGTAGTCTTTGCTACTCAGGAGGTTGAGGTGGGAGGATTA ACTGAACCTGGGGAGCTGAAGGCTGCAGTGAGCCGTGATTATGCCACTGTACTCCAGCCTGGGCAACAGT GTGAGACCCTATCTCAAAAAATAAAAAAATAAAAAAAACATAAAGAGATGTTCGACCTCACTCTTAATAA TACAAATGTGGAATAAACTACAACGAAATATTCTTTTTTTAAACTTTTATACTTTTTATCACAGTGATAA AGATCAAAACATTTGAAAATGTGATCTGTTATTTGTCTTTCGCCTGTGTGTCTATAGAATTATGCAATTT TTACTGATTTGGAGGAGCTTTGTGCATATAAGGAAATTAGCTCTTGTGATAAGTATTGAAAATACATTTT TTCAGTATCTTACTTTTCTTATGATTTTTGTATCGATTTTTCTGAAGTCTTTTGTTTAAATCTTTTATTT CATGATGTGTAGGCTTTGTGTCATTTCAGAAGGCCTTCTCCACTCCAAGGTTTAAAAAATCATTTCCTGG CCAGGCGTGGTGGCTCACGCCGTAATCCCACTTTGGGAGACCGAGGCGGGTGGATCACGAGGTCAGGAGA TCGAGACCATCCTGGCTAACACGGTGAACCCCCGTCTCTACTAAAAATACAAAAAAAAAATTAGCCGGGT GTGGTGGCGGGCGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCAGGAGG CGGAGCTCGCAGTGAGCCGAGATCACATTACTGCACTCCAGCCTGGGCGACAGAGCAAGACTCCATCTCA AAAAAAAAAATCATTTCCCATCTTTTCTTCTAAAACTTTAATTTTTAGAAAAACAATGTAGTTATTTTTT TATCCATCTGGACTTTTATGTAAGAAATGGGGTAAAGCTCCACCTTATTTTTTCCCCAGATAATTTCTTA GTTGTCCTTGAAGATGTATTTAATAATCTCTCTTTTTCCTGGGGAGTTTTATTTTTAAGGTATGAAACAA TATTCACAATGAGGGAAAAAAAGGAAAACAAATTAGACATTTTTAAAACCTGATTGTTACCACAGATATA AAAAGATTGAGAAAAATTACAGTTTTTTTTTTGTTGTTGTTTGTTTGTTTGTTTTAATGAGTCTTGCTGT ATCACCCAGGCTGGAGTACACTGTCGTGATCTTGACTCACTGCAACCTCCACCTCCTGTGTTCAAGCAAT TCTTCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCGTGGACCACCACGCCTGGTTAATTTTTATAT TTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCCGACCTCAAGTGATCTGC CTGCCTCAGCCTCTCAAAGTGCTGGGATTACAGGCATGAGCTACCGCACCTGGCTGACACAACCTTTATT TTTTTTATTTTTCGAGACGGGGCCTTGCTCTGTCGCCTAGGCTGGAGTGCAGTGGTGCCATCTCCGCTTA CTGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGC ATGTGCCACCACATCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTG GTCTCGGACTCCTGACCTTGTGATCCACCCGCCTCGGCCTCCCAAGTTCTGGGATTACAGGTTTGAGCCA CCATGCCCAGCCGACACAACCTTTTTATTAACTGCCTGATGTTTCTCTAAAGCATTTTACTCCAGAGAGG TCCCCCCATTTTAAATATATTGTGCAATAAAAGTAAACATCCAGTAAAATTGACTTTTTCTTGTACAGTT CTAAGTTTAGACAAACACATAGACTTATGTAACCAGCCACCACATTGAATTCAAGATAGAGAATCGTCCT TTAACCCCCATATATTCTCTCATGCTACTATTTTGTAGGCAAATCCTGCCCTCACCCCAATCCCTGGCAC CCACTGCTCTGTTTTCTGCAAGTACCTATGTACTCAGAATTTCTGGTGACTGTTTTTGGGTTTTTTGTTT TTTATTTTTTTGTTTTTGAGGCAGAGTCTCATTCTTTTGCCCAGGCTGGAGTGCAGTGGCGCCATCTCAG CCCACCGCAACCTCCACCTCCTAGGTTCAAGCAATTCTGTTGCCTCAGCCTCCCGAGTAGCTGGGATTAC AGGCATGTACCACCACGACCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCTTGTTGGCCAG GCTGGTCTTGAACTCCTAGCCTCAGGTGATCTGCCCGCCTTTGCCTCCCAAAGTGCTGGGATTACAGGTG TGAGCCACTGCGCCTGGCCAACTGGTGACTGAATTGAGTCAAGTGGGAACTGTTGCCTGAGGACATTGCT TCTTAACTGGCAGGAACTTGCTCTGCACCCTGGAATATACTCTGAAGGCTGGGAGCAGTCAGAGGCCTCA GACAAATAATCATAAGAGTTAACATTTCCTGAGCGCTTACTACATGACAGGTACTGTGCCAAGGGCATTT AAAGCATTATATCACTTTTCACAGCAGTTCCATGAGGTAAATCTATCATCCCCATTTTACAGATGAGGCA ACTGAGGCTAAAGATAAAGTACTTTGCCCAAGATCATACAGCCAGGAAAGAGTGGAGCCAAGATTTGGAC CCAGGCTGGGCAGTTGCCATGCACATGCCCCTTACCTCTCTACTATGTTGCCTTCCCCCGAAAAGAGTGG TTACCTGTCTCTACCACCCCCAGCCTGGAAATGTGACCGGCACCCATGTTGGCTCTCACATCCTCATATT CTCTCCTAATGCAACTTCTTGCTTGGGAAATAGATATTGCTGAAGCAGGGTTGATTCAGGAAGGGCTTCT GTGATGGGCAGGGCGGAGGACTAGGCTGGGGACGGGTGCTGGGAGATTGCCGCCTGTTTCTGTCTTGCTG ACAACATTTTTCCCCTCTCCGCACTGGACAGAGCCTCTTCTGTTCCTCTCCATCTGACTTCCTGCTTCCT CCTCTGGCTTTGGAGTGCCTGGCTCCTCTGACTACCTCTTCTTAAGCCCCCATCTCTTCTCTCTCACTCC GCTTGGTAAGAGGAACAAGGGTTCTGGGGTCTGGGCAAAGGGAAACATCTCCTGGCTCTAGCAAATGGGC CCCGTGAGAGTTGGGTGCACCCCTGAAAAGGTAAATCCACCCCGGGGAGCTCTACCAGAGGCATTACCAC TCCCTAGCAGGGCATCTGGAAGTGGCAGTTATTTTCTTAAAACTTAAATGATAGTAAGCATACAGAATAG CGCACAGATCATGAGCTTGGTTTCCACAAGGTGAATACACTCATGTAACCAGTATCAGATCAGGAGATAG AATATTCCCAACATCCCATGTAACCAGTACCAGATCAAGAAGTAAAACATTCCCAGCAGCCCAGAGGTTC CTCTCCAGGCTCCCTTCTAGTCACCGTCCCTAGAGTAGAGGGCTGGGGCATTTTTGTTTGTCACAATCAC TTCTGGGTTCTACTGGCATTGAGTTGGCAGAGTCTAGTGTCTGCAATGCATGGGACAGTCCTATGGTATA AAGAACTGTCCTGCCCAGATGCACTGTTGAGAAACACTGTACCTGCCAGGTCTGACCAGTGATGGGCTGC AGTGTGGCAAAGGCCTGGAGGACAGGGGTGAAGCTGCGTCTGTGGGTCAGAGTGAGGAGGGGCCTTCACT GCAATGCTGTTGCCACCCCCAGGCCTCCGGAATGCCCCCCGCTGCTGGGCAGTGATCCAGCCCCTGCTGT GTGCCGTATACATGCCCAAGTGTGAGAATGACCGGGTGGAGCTGCCCAGCCGTACCCTCTGCCAGGCCAC CCGAGGCCCCTGTGCCATCGTGGAGAGGGAGCGGGGCTGGCCTGACTTCCTGCGCTGCACTCCTGACCGC TTCCCTGAAGGCTGCACGGTGAGTGCTCTGTGAGACAAGGTCCAGGCTCTCTGGGTTGGGCAGGACCGGG TATAGGGCAGGGTCCAGTGGGGAGCAGGGGAGCCCAGAGCTTTGTCTCCTGGAGACCCTGAGCCTACAGC CATGGGGTCAACAGGACACAAACTCAAACTGCAGCTCACTGGCTGGATCCGTCTATTAGGGATTCTCTAT TTATTTATCAATGATCACATGTTCAGCAAAATGTTTTGAGCACTGGCTGTTGGGTGTTGTGGTGTTACGG GCATCACGGATGACAGGAGCCTATCAGGAAGTTTCTCATGTATGTTGGGAGTTAAGGCGCGAGCGTGTGA AACAGCTAGAGCCACCAAGACAGGGGACGTGAGCTAGTTCTGGGTGGTGCAGGAGAGGTCTTCAATGAAA ATAATAACAGTAATAATGATGGTAATAATACTAATTAGTCCTGTTTACTATATGCCAAATGCCATTATAA TAAGCTCATGCCTGTAATCCCAGCACTTTGGGAGGTCGAGGTGGGCAGATCACCTGAAGTCAGGAGTTCC AGACCAGCCTGGCCAACGTGGCAAAACCCTGTCTCTACTAAAAATACAAACATAAGCCTGATGTCATGGT GTGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGACACGAGAATCGCTTGAACCCGGGAGGTGGAAGTT GCAGTGAGCTGAGATCGTGCCACTGAACTCCAGCCTGGGCTACAGAGTGAGACTCTGTCTCAAAATAAAT AAATAAATAAATAGGCTGGCCAGACACAGTGGCTCATGCCTGTTATCCCCACCACTTTGGAAGGCTGAGG CGGGTGGATCACTTGATGAGGTCAGAAGTTCAAGACCAGCCTGACCAACATGGTGAAACTCCGTCTCTAC TAAAAATACAAAAAATTAGCCAGACATGGTGGTGGGCACCTGTATTCTCAGCTACTTGGGAGGCTGAGGC AGTAGAATCGCTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCAAGATTGTGCCATTGCACTGCAGCCTG GGCGACAGAGCCAGACTCTGTCTCTCTCTTTCTATATATATAATATATGTTTATTCATTTAACCCTTAAA CCATACCATAAGGTAAGTACTACCATCTTAGAAATGGGGAAACTGGCCGGGCGCAGTGGCTCACGCCTGT AATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCATGAGGTCAGGAGTTCAAGACCAGCCTGGCCAAC CTGGTGAAACCCCGTCTAAAATACAAAATTTAGCCGGGTGTGGTGGTGGGCGCCTGTAGTCCCAGCTACT CGGGAGTCTGAGGCAGGAGAATTGCCCGGGAGGCAGAGGTTGCAGTGAGCTGAGATCACGCCACTGCACT CCAGCCTGGGCGACAGAGCGAGACTGTCTAAAAAAAGAAAGAAAAAAAGAAAGAAAGAAGTGGGGAAACT GAGGTACAGAGAGGCCAAATAATTTGCCAAGCCAGCCCTGGGATTCAGGTCCTGGAAGTGTATCTCCAGC CACCCTGCCATGCTACCTAGATACCTTTCCCTAAACAAGAGGCTCGTCCCTGAGCTGCCTTGACACCGTC TTTTCCCATCCCTGGTGCCAGAATGAGGTGCAGAACATCAAGTTCAACAGTTCAGGCCAGTGCGAAGTGC CCTTGGTTCGGACAGACAACCCCAAGAGCTGGTACGAGGACGTGGAGGGCTGCGGCATCCAGTGCCAGAA CCCGCTCTTCACAGAGGCTGAGCACCAGGACATGCACAGCTACATCGCGGCCTTCGGGGCCGTCACGGGC CTCTGCACGCTCTTCACCCTGGTCAGCCGCGGGAGGGCAGGCCCGGGGGGCCCTCAGCCTGGAACGTGGG AAGAGAGCCAGAGGGAAGGGGGGCAAAGAGGTCTTGGTGGGGGTCCCCAGGGAAGGGTCATGATCAGAAG GGTCTGGGGCTCAGTTAAGGGTGTCTGTGTCAGCAGAATAACCCTAACCTCACAGAATGGCCCACTTCTC TCTTCTAGGCCACATTCGTGGCTGACTGGCGGAACTCGAATCGCTACCCTGCTGTTATTCTCTTCTACGT CAATGCGTGCTTCTTTGTGGGCAGCATTGGCTGGCTGGCCCAGTTCATGGATGGTGCCCGCCGAGAGATC GTCTGCCGTGCAGATGGCACCATGAGGCTTGGGGAGCCCACGTAGGTGTCTTGGGGACCCAGAGGTGAAG GTACAGGGAGGAAGGCTGAAGTGTGCGTTTACCCCAAAGGGAGCAGGTGCGTGTAAAACCGAGATCCAGG GCAGGATCTGGCTCTGCCCTACTGCATACTGCATGCAAGATCTCCAGTGTTAGGATCTTAGTTTCAGAAT CAGGACCTTCATGGTTTGTATCTGCTCAAAGGGGCGGCTCCTAGAGCCTCCTCAGATCTGACCTGGGTCC TGTCTCCAAGCCCTGACTTCTGGGAACCTCCAGACCTCAGCAGCTGAGGGTCTGGGCACAGGGTGGGGAG ACCAGGTAGAGGGAGTACAGAGTGACCGCCTCAAGTGACACCTCACCTCTCTGCACAGCTCCAATGAGAC TCTGTCCTGCGTCATCATCTTTGTCATCGTGTACTACGCCCTGATGGCTGGTGTGGTTTGGTTTGTGGTC CTCACCTATGCCTGGCACACTTCCTTCAAAGCCCTGGGCACCACCTACCAGCCTCTCTCGGGCAAGACCT CCTACTTCCACCTGCTCACCTGGTCACTCCCCTTTGTCCTCACTGTGGCAATCCTTGCTGTGGCGCAGGT ATAGTGACTGGTAGGAACGGGAGACCTGGATGGGGTGAGTTTGAGGGAGGGGGCCAGTAACCCACCTTCT GTCCCACCCCTTCCTGCTGCAGGTGGATGGGGACTCTGTGAGTGGGATTTGTTTTGTGGGCTACAAGAAC TACCGATACCGTGCGGGCTTCGTGCTGGCCCCAATCGGCCTGGTGCTCATCGTGGGAGGCTACTTCCTCA TCCGAGGTGAGTGAAGACCAGGCCAGGACCAGTTGGGCAACAAAATATACTGGGCACTTGCTGCCAGTAC TGGGAGCTGCCAGCACGGCTGCCCCCATGCTGAAACCCCAGCTAGCTCCTATAGGGCCTTCACACAGTAG AAGGTGACCCTCTAGGCAGACGAAACACCGTGAGCACTTGCTGCGGGACAGCACCTTTGTACTGGCCAGA AAAATCCATCCCTCTCTCCAGGGCCTTGGCCCAGGGCTCACAGCTTGTTTTTTTTGTTTGTTTTTGTTTT TGAGACAGAGTCTAGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAATCTTGGCTCACTGCAACCTTCG CCTCCTGGGTTCAAGTGATTCTCCTGCCTCACCCTCCCCCATAGCTAAAATTACAGGCATGCACCACCAC GTCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGCTGGTCTTGAACTCC TGACCTAAAGTGATCCACCACCTCAGCCTCCCAAAGTGCGGAGATTACAGGCATGAGCCACAGTGCCCAG CCTCACAGCTTGTTAGGTGGAGTTGGGTCAGGATCCAGCCCCAGTCAGCTCCTGGCCGGTGCACTTGTGT GATGAACACCCTGAGTAACCTACTCTGCCCACTTGGACCAACCTAGGTCGTTTGGTTATCTGTGTGCACA TTAATTCGATATGTACTGTCAATCTTCTGGAGCTTGGTTTTCATCTTCTTTCTGTCCCCGGCACACACAG CTCTCACAGCATGCGTGGAATTAGTGGTCCCTAACTTTCCTGTCTCATGCTGCCATCCCATAGTAAGCCT CAGCATCTATTTAGCTCATTGTTGTTGGGTTTTCTTTGTAAACCTCAGTTTCCTCACCCTGAACTGCCAG CCTTCTGTTCAGTCACCTCTTTCCCCTCTTTTTGGCATAGTGTCTGGCCCTCTGATTTGTGCTTCGTTAT CATGCTGTCCTAGTATGGTAATCACTAGCCACATGTGTTGAACTAGTCCAGCCTGGGTGCGGCGGCTCAC TCCTGTAATCCCAGTACTTTGGGAGGCTGAGACGGACGGATCACTTGAGCTCAGAGTTCGAGACCAGCCT GAACAACATAGTGAAACCCCATCTCTACAAAAAATACAAAAGTTGCCTGGGCAGGGTGGCACATGCCTGT GGTCCTAGCTATGTGAGAGGCTGAGGTGGGAGGCTTGCTTGAGCCCAGGAGGTTGAGGCTGCAGTGAGCC ATGATCTTGCCACTGCACTCCAGCCTGAGTGACAGAGTGAGACCCTGTCTCCAAAGAAAACAAGACAACA ACAAAAAGAAACAAGTCCAAATTGAGATGTGTTGTAAAATGTGAAATACACACTGTATTAAAAAAAAAAC TTAGTGGGAAAAAAATGTAAAATATCTCATTAATAATTTGTTACATGGATTACATGTTGAAATGATTTTA TTTTGAATATATTAGGTTTGTAAAATATATTGATATTAGTTTTGCTTGTTTCTTTTAACTTTTTTTAAGT GGCCACTAGAAATTTGCCATATGTATGTGGCTCACATATTTCTATGGGAAGGCCGGCATGGTGGCTCACA CCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACCTGAGTTCAGGAGTTCAAGACCATCCT GGCCAACATGGTGAAACCCCATCTTTACAAAAATACAAAAATTAGCCGGCGTGATGGTAGGTGCCTGTGA TCCCAGCTGCTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCGGAGTTTACAATGAGCCGA GATCACGCCATTGCACTCCAGCCTGGGCGACAGGGTTCCATCTCAAAAAAAAAATTATATGGATAGCGCT GTTCTTGAGTCTGTTTTATGTCTTTCCCATCAGAACAGCTTTGATCTGCCCCCTTCTTCAGGGGCAGCTG GGCCACGACCGAGGCTCCCTCTTCTCAAGTGTCTGTCTAGGCTCTGCCCTGGTCTTCTCACCATTTCTCC AGTGTCTCTAGCTCCCCAGGTTTTCATTTAGCACAGGGGTAATCAGACTTGGGACTCCAGAGCCTTAGGA CCCTCCTCCCACTCACCCATCCTTCCCAGCAGGGCAGCCTCACCCCTGCTAATGTCTGAGGTCCCCCTTC TGTTCAGGAGTCATGACTCTGTTCTCCATCAAGAGCAACCACCCCGGGCTGCTGAGTGAGAAGGCTGCCA GCAAGATCAACGAGACCATGCTGCGCCTGGGTGAGTGGCCCCGGGGGACTTCGGTCTGAGGTCCTGGCCA GCCCAACACTGCACCCTCCTGGGGCTATGCGACCGGCAGGATGCAGTAAGTCAGTGGGACAAGTTAGCCA TAGGGACAAGGACAAGGGGTGTGTGTAGGTGGTAGTGGTAGTGGCAGCTCAAAAGAAGGGGGTCTACTCG GGGGGAAGAATTCAGTCAAGTTCATGCCGGGACTGGTTCCTCCTGCCCACTACGTCCCACGTGGTCCCTC CCACAGTTGCTTCAAGTGCCCTTCTTATTTTATTTTAGAGAAAGCAGTTCTTGGACTGAGCCCAGCATGA GTTCACCCCAGCCCCAGCTGGGTGAACTTTGAGGCCCAGTGGGGCAGACTCTCTCCTCCCCACTGCTGCT GCGGGACTGGGCTTGGTAACGTCCTGTCCTGCCCCTGTCCTCCACAGGCATTTTTGGCTTCCTGGCCTTT GGCTTTGTGCTCATTACCTTCAGCTGCCACTTCTACGACTTCTTCAACCAGGCTGAGTGGGAGCGCAGCT TCCGGGACTATGTGCTGTGAGTGAGGGGCATGGAGGCGGCAGTGCTGGGAGCTGGAGCCAAGGCCATAAA GACACCCACCTCCACCCACCGGGCAGCAGGGATTTGCCAGGTCCCTGCTGCAGACAGCAGATTCAATGGA TGGTGTCTGGGTGCATAAGGCATCAGTCTCCGTAGTTTCTCAAACGTGGCAAACAACCTTCGCATCCCTT CTCACCTCTGCCCTTCCCTCTCCACCCCCTTGGTTGCCCAGCTGGTGCATGTGTGACTGTTAAGCAGCCA GTTCAGCTTCGTCTTCTCTGACTGACACTAAGTTGCCCTCTAATTCTGTGTGCTCTCCTGCAGAGCCTGC TTTAGATCCTGGCACAGGACTAGTTACCTCTCTGTGATAGGTTAATGACCTGCTAATGTTGGCTAGTTTT TGCCTGTGCTTTTTTGTGTCATAATGAGGATGGATTGGAGAGAGTAAGACATTGCTACTGCTGAGAGAAG CGCAGTACCCACTGTTACAAGGACAGTCGCTAAAATGGATGCTAGTCCAAGCCCTGACTGCTTCAGGCTC TTCCGTAAAGGTTCCGGCTTCCAGTCTGGGATGCTTTAAACCACAGTGATGCCTGAGTCTCTGCCCCAGA GATTCAATTTAATTGTCTAGGGTGGGTCCCAGGCATCAGTAGCTATTAAAAGCTCCCCAGTTGATTCTAA TGAGCACCCAGGGTTGAGATCAGTGCTGTGGAGCTTAGCCCTTTCTAAAGTTTTTGGATTGATTGTCTGA GTCTACCCAGTAGACTCAGAAAACCCCACCTGTAGTCCCAGCTACTTGGGAGGCTGAAGCAGGAGATTGC CTGAGCCCAGGAGTTGGAAGCTGCAGTGGGTTGTGATCACGCCACCGCACTCTAGCCTGGGTGACAGAGC AAGATCCTATCTCAAAAAAAGAGAGAGGAAAAGAAAGGAAAGCCTCACCTGTCTACGTTCCCTCACTGTA GATGTCAGGCCAATGTGACCATCGGGCTGCCCACCAAGCAGCCCATCCCTGACTGTGAGATCAAGAATCG CCCGAGCCTTCTGGTGGAGAAGATCAACCTGTTTGCCATGTTTGGAACTGGCATCGCCATGAGCACCTGG GTCTGGACCAAGGCCACGCTGCTCATCTGGAGGCGTACCTGGTGCAGGTGGGCATGGCAGCCAGCCCCTC CTGCCCTGCCCGCCTCACCCTCAGCCTTGGGACCCCATCTTTAGGTTTTGTCGGGTCCTGCCTCTAGCAC AGCCTTGGTCAGTGGTTCACCGCTGCCCCCTGGTGGCACCTTCTGTCCTTGGGTGGCCTGATGCCTGGGC CTGGGCCTGGGCCAAGGGCAGAGCCAGCTGCCATCACCTTTTAAGAGCGGAGTGATTGGAGGGCTGGGCA CACAGGAGCTCTGCATTCTGGCCCCACTTCTTTGCAGAGAAGGCCTCTACTCCTGAGTCCTTGAAGGACT TGAGGCCCTTGGGAGCCTCCTTCTCTGGAAAGAATGGCATCGCTGGCCCTTCCCAAGATTTGATGGGAAG TGGCAGCTTCTTCACGCTCCTTCCCTATCCCTTCTGCTCTCAGGTTGACTGGGCAGAGTGACGATGAGCC AAAGCGGATCAAGAAGAGCAAGATGATTGCCAAGGCCTTCTCTAAGCGGCACGAGCTCCTGCAGAACCCA GGCCAGGAGCTGTCCTTCAGCATGCACACTGTGTCCCACGACGGGCCCGTGGGTGAGCCTCACCCCTCCT CTACCGGAGCCGCCTGGCCCCGCGCTGCCCATGTGCTAGTCTCTCCCAGCCTGCTGGGGGCACACAGATT ATTTGGAAGACCGACTGTGAGGAGCAAGGCGCTCCCTCCATCGCTCACACACCCATTCTTCCCCCGGCCC CTCCTACCCTCTGGGGGGCTCTCCCCTCTCTGTTTCTGCCCCTGGGTCTGCTTGCCGGTGCTTGGGTTCC AAGAAGACTCCCCTCCCTCTCCCTTCTCATAAATTCTCCAGTTGCTCTCCCTGGGCAAGAGTAAGTCAGG GTTCCAAGAACTGGATTTCTGGCCTCCAGTTAGGCCCTTTGGGGACGTGAGGCCCTTCTCTTCAGATTCT GAAGGGGTAGAGATCACCGTGGTTACAGGGTGAGCTTTCTCTGGTGAGCAGGAGGGACTGGCTGTGGGAA GATGAATGGCACTGACTATGGGAGGCACTGCCAGGGACCGGGAAGTCACTATTCCTTCTCCTTTCCTTCC TTCCATTCCCACAGCGGGCTTGGCCTTTGACCTCAATGAGCCCTCAGCTGATGTCTCCTCTGCCTGGGCC CAGCATGTCACCAAGATGGTGGCTCGGAGAGGAGCCATACTGCCCCAGGATATTTCTGTCACCCCTGTGG CAACTCCAGGTATGAGAGTTCAAGCTTCTGGAGGAAGGTGGGGGGAGCACAGAGGCTGGGGGCTTCTGGG ACTGGAGTACAGGGGCTGTCGGAGGAGGAGGAAGAGGAAGGAAAGGCCCCAGAGGATCTGAAGAGTGGGG CTGAGGCTCTAAGAGTCTAGAGACCTGGGCCCCAGAACTAACAGGTTAAGTGCTCCCAGGGGAGCGGGGG TGGCATGGACAGAGCCAGGGCCCCAGGCTCGTGTTGTCTCTCCTCCTGTCAGTGCCCCCAGAGGAACAAG CCAACCTGTGGCTGGTTGAGGCAGAGATCTCCCCAGAGCTGCAGAAGCGCCTGGGCCGGAAGAAGAAGAG GAGGAAGAGGAAGAAGGAGGTGTGCCCGCTGGCGCCGCCCCCTGAGCTTCACCCCCCTGCCCCTGCCCCC AGTACCATTCCTCGACTGCCTCAGCTGCCCCGGCAGAAATGCCTGGTGGCTGCAGGTGCCTGGGGAGCTG GGGACTCTTGCCGACAGGGAGCGTGGACCCTGGTCTCCAACCCATTCTGCCCAGAGCCCAGTCCCCCTCA GGATCCATTTCTGCCCAGTGCACCGGCCCCCGTGGCATGGGCTCATGGCCGCCGACAGGGCCTGGGGCCT ATTCACTCCCGCACCAACCTGATGGACACAGAACTCATGGATGCAGACTCGGACTTCTGAGCCTGCAGAG CAGGACCTGGGACAGGAAAGAGAGGAACCAATACCTTCAAGGCTCTTCTTCCTCACCGAGCATGCTTCCC TAGGATCCCGTCTTCCAGAGAACCTGTGGGCTGACTGCCCTCCGAAGAGAGTTCTGGATGTCTGGCTCAA AGCAGCAGGACTGTGGGAAAGAGCCTAACATCTCCATGGGGAGGCCTCACCCCAGGGACAGGGCCCTGGA GCTCAGGGTCCTTGTTTCTGCCCTGCCAGCTGCAGCCTGGTTGGCAGCATCTGCTCCATCGGGGCAGGGG GTATGCAGAGCTTGTGGTGGGGCAGGAACGGTGGAGGCAGAGGTGACAGTTCCCAGAGTGGGCTTTGGTG GCCAGGGAGGCAGCCTAGCCTATGTCTGGCAGATGAGGGCTGGCTGCCGTTTTCTGGGCTGATGGGTGCC CTTTCCTGGCAGTCTCAGTCCAAAAGTGTTGACTGTGTCATTAGTCCTTTGTCTAAGTAGGGCCAGGGCA CCGTATTCCTCTCCCAGGTGTTTGTGGGGCTGGAAGGACCTGCTCCCACAGGGGCCATGTCCTCTCTTAA TAGGTGGCACTACCCCAAACCCATCTTTTGTTCTCCTATATCCTCCTTCTTCTGTTCCATTTCAGTTCAG TTTCAGCGGTGCCAACCTCTTTGCGTTTCCTTTTTGTTGATGAGGACCCAGAGCTGCTGCACACACTCAC CTCTAACCCCCTCCCCTCGCTGCTGGGCCCCATCTCCACAGGAGAGACTGGTTCAGCTCTAGGGCCTCAG TCTGGAGTGGGATAGGAGCAGTGAGTGACAAAGCCTCTGAAAGATGCATCATCTCTTCCTCACACCCATT TAGTGGGGGATGGGTCCTCTAGACTTGAGGGGCTACCCTGGGAAGCTGCCGTAGCTTCAGCCAGGCAAGA AAGCTTCCTTCAACCTGCATAGCCGGTGGGTGAGGAGATTCCCACCTTCCATAGCCTCCAAACATGTTCC CAAGGCCCCACTTTCAAGAATCAGACAGCAGGAAGCCATAGATGCTGGCTGGGTTCCAGGTTATGGGGAG AAGAAATACAGTCAATAAAAGGTTTTTGTATAAAC Download Select all
Length	24675
OMIM ID	601500
HGNC ID	HGNC:11119
Unigene ID	Hs.437846
Ensembl ID	ENSG00000128602
PharmGKB ID	-

mRNA Information

mRNA ID	NM_005631.4
Exon	join(1..611,14513..14718,16332..16541,16739..16911, 17279..17498,17593..17716,19888..19980,20418..20526, 21492..21677,22094..22242,22765..22899,23153..24674)
mRNA Sequence	>6608 GGGCTGAAGACAACTTGGATTGCGAGGCTAGGGCTTGGGGAGTCGTGCATCCCGTTCCGGGCCT CCGCAGCCCAACATGGGCCCCGGGTTCCAAAGTTTGCGAAGTTGGGCGCCGAGGGGCCGGGGCG CGCGGAGCGTCCGGGGGGGCCCGGGCCCGGATTCTCTGGGCGCACAGGTCGCCTGAGCCGCCTC CGCGGCCGCCGAGGTCGTGCGTGTGGCCGGGGGGCTCCGAGGAGCAGGCGGGGGCGCCGGGGCT TTTGCTGAGTTGGCGGGGTTGGCCATGGCCGCTGCCCGCCCAGCGCGGGGGCCGGAGCTCCCGC TCCTGGGGCTGCTGCTGCTGCTGCTGCTGGGGGACCCGGGCCGGGGGGCGGCCTCGAGCGGGAA CGCGACCGGGCCTGGGCCTCGGAGCGCGGGCGGGAGCGCGAGGAGGAGCGCGGCGGTGACTGGC CCTCCGCCGCCGCTGAGCCACTGCGGCCGGGCTGCCCCCTGCGAGCCGCTGCGCTACAACGTGT GCCTGGGCTCGGTGCTGCCCTACGGGGCCACCTCCACACTGCTGGCCGGAGACTCGGACTCCCA GGAGGAAGCGCACGGCAAGCTCGTGCTCTGGTCGGGCCTCCGGAATGCCCCCCGCTGCTGGGCA GTGATCCAGCCCCTGCTGTGTGCCGTATACATGCCCAAGTGTGAGAATGACCGGGTGGAGCTGC CCAGCCGTACCCTCTGCCAGGCCACCCGAGGCCCCTGTGCCATCGTGGAGAGGGAGCGGGGCTG GCCTGACTTCCTGCGCTGCACTCCTGACCGCTTCCCTGAAGGCTGCACGAATGAGGTGCAGAAC ATCAAGTTCAACAGTTCAGGCCAGTGCGAAGTGCCCTTGGTTCGGACAGACAACCCCAAGAGCT GGTACGAGGACGTGGAGGGCTGCGGCATCCAGTGCCAGAACCCGCTCTTCACAGAGGCTGAGCA CCAGGACATGCACAGCTACATCGCGGCCTTCGGGGCCGTCACGGGCCTCTGCACGCTCTTCACC CTGGCCACATTCGTGGCTGACTGGCGGAACTCGAATCGCTACCCTGCTGTTATTCTCTTCTACG TCAATGCGTGCTTCTTTGTGGGCAGCATTGGCTGGCTGGCCCAGTTCATGGATGGTGCCCGCCG AGAGATCGTCTGCCGTGCAGATGGCACCATGAGGCTTGGGGAGCCCACCTCCAATGAGACTCTG TCCTGCGTCATCATCTTTGTCATCGTGTACTACGCCCTGATGGCTGGTGTGGTTTGGTTTGTGG TCCTCACCTATGCCTGGCACACTTCCTTCAAAGCCCTGGGCACCACCTACCAGCCTCTCTCGGG CAAGACCTCCTACTTCCACCTGCTCACCTGGTCACTCCCCTTTGTCCTCACTGTGGCAATCCTT GCTGTGGCGCAGGTGGATGGGGACTCTGTGAGTGGGATTTGTTTTGTGGGCTACAAGAACTACC GATACCGTGCGGGCTTCGTGCTGGCCCCAATCGGCCTGGTGCTCATCGTGGGAGGCTACTTCCT CATCCGAGGAGTCATGACTCTGTTCTCCATCAAGAGCAACCACCCCGGGCTGCTGAGTGAGAAG GCTGCCAGCAAGATCAACGAGACCATGCTGCGCCTGGGCATTTTTGGCTTCCTGGCCTTTGGCT TTGTGCTCATTACCTTCAGCTGCCACTTCTACGACTTCTTCAACCAGGCTGAGTGGGAGCGCAG CTTCCGGGACTATGTGCTATGTCAGGCCAATGTGACCATCGGGCTGCCCACCAAGCAGCCCATC CCTGACTGTGAGATCAAGAATCGCCCGAGCCTTCTGGTGGAGAAGATCAACCTGTTTGCCATGT TTGGAACTGGCATCGCCATGAGCACCTGGGTCTGGACCAAGGCCACGCTGCTCATCTGGAGGCG TACCTGGTGCAGGTTGACTGGGCAGAGTGACGATGAGCCAAAGCGGATCAAGAAGAGCAAGATG ATTGCCAAGGCCTTCTCTAAGCGGCACGAGCTCCTGCAGAACCCAGGCCAGGAGCTGTCCTTCA GCATGCACACTGTGTCCCACGACGGGCCCGTGGCGGGCTTGGCCTTTGACCTCAATGAGCCCTC AGCTGATGTCTCCTCTGCCTGGGCCCAGCATGTCACCAAGATGGTGGCTCGGAGAGGAGCCATA CTGCCCCAGGATATTTCTGTCACCCCTGTGGCAACTCCAGTGCCCCCAGAGGAACAAGCCAACC TGTGGCTGGTTGAGGCAGAGATCTCCCCAGAGCTGCAGAAGCGCCTGGGCCGGAAGAAGAAGAG GAGGAAGAGGAAGAAGGAGGTGTGCCCGCTGGCGCCGCCCCCTGAGCTTCACCCCCCTGCCCCT GCCCCCAGTACCATTCCTCGACTGCCTCAGCTGCCCCGGCAGAAATGCCTGGTGGCTGCAGGTG CCTGGGGAGCTGGGGACTCTTGCCGACAGGGAGCGTGGACCCTGGTCTCCAACCCATTCTGCCC AGAGCCCAGTCCCCCTCAGGATCCATTTCTGCCCAGTGCACCGGCCCCCGTGGCATGGGCTCAT GGCCGCCGACAGGGCCTGGGGCCTATTCACTCCCGCACCAACCTGATGGACACAGAACTCATGG ATGCAGACTCGGACTTCTGAGCCTGCAGAGCAGGACCTGGGACAGGAAAGAGAGGAACCAATAC CTTCAAGGCTCTTCTTCCTCACCGAGCATGCTTCCCTAGGATCCCGTCTTCCAGAGAACCTGTG GGCTGACTGCCCTCCGAAGAGAGTTCTGGATGTCTGGCTCAAAGCAGCAGGACTGTGGGAAAGA GCCTAACATCTCCATGGGGAGGCCTCACCCCAGGGACAGGGCCCTGGAGCTCAGGGTCCTTGTT TCTGCCCTGCCAGCTGCAGCCTGGTTGGCAGCATCTGCTCCATCGGGGCAGGGGGTATGCAGAG CTTGTGGTGGGGCAGGAACGGTGGAGGCAGAGGTGACAGTTCCCAGAGTGGGCTTTGGTGGCCA GGGAGGCAGCCTAGCCTATGTCTGGCAGATGAGGGCTGGCTGCCGTTTTCTGGGCTGATGGGTG CCCTTTCCTGGCAGTCTCAGTCCAAAAGTGTTGACTGTGTCATTAGTCCTTTGTCTAAGTAGGG CCAGGGCACCGTATTCCTCTCCCAGGTGTTTGTGGGGCTGGAAGGACCTGCTCCCACAGGGGCC ATGTCCTCTCTTAATAGGTGGCACTACCCCAAACCCATCTTTTGTTCTCCTATATCCTCCTTCT CCTGTTCCATTTCAGTTCAGTTTCAGCGGTGCCAACCTCTTTGCGTTTCCTTTTTGTTGATGAG GACCCAGAGCTGCTGCACACACTCACCTCTAACCCCCTCCCCTCGCTGCTGGGCCCCATCTCCA CAGGAGAGACTGGTTCAGCTCTAGGGCCTCAGTCTGGAGTGGGATAGGAGCAGTGAGTGACAAA GCCTCTGAAAGATGCATCATCTCTTCCTCACACCCATTTAGTGGGGGATGGGTCCTCTAGACTT GAGGGGCTACCCTGGGAAGCTGCCGTAGCTTCAGCCAGGCAAGAAAGCTTCCTTCAACCTGCAT AGCCGGTGGGTGAGGAGATTCCCACCTTCCATAGCCTCCAAACATGTTCCCAAGGCCCCACTTT CAAGAATCAGACAGCAGGAAGCCATAGATGCTGGCTGGGTTCCAGGTTATGGGGAGAAGAAATA CAGTCAATAAAAGGTTTTTGTATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA Download Select all
Length	3772

CDS Information

Location	join(281..611,14513..14718,16332..16541,16739..16911, 17279..17498,17593..17716,19888..19980,20418..20526, 21492..21677,22094..22242,22765..22899,23153..23580)
CDS Sequence	>gi\|300116182:281-2644 Homo sapiens smoothened, frizzled family receptor (SMO), mRNA ATGGCCGCTGCCCGCCCAGCGCGGGGGCCGGAGCTCCCGCTCCTGGGGCTGCTGCTGCTGCTGCTGCTGG GGGACCCGGGCCGGGGGGCGGCCTCGAGCGGGAACGCGACCGGGCCTGGGCCTCGGAGCGCGGGCGGGAG CGCGAGGAGGAGCGCGGCGGTGACTGGCCCTCCGCCGCCGCTGAGCCACTGCGGCCGGGCTGCCCCCTGC GAGCCGCTGCGCTACAACGTGTGCCTGGGCTCGGTGCTGCCCTACGGGGCCACCTCCACACTGCTGGCCG GAGACTCGGACTCCCAGGAGGAAGCGCACGGCAAGCTCGTGCTCTGGTCGGGCCTCCGGAATGCCCCCCG CTGCTGGGCAGTGATCCAGCCCCTGCTGTGTGCCGTATACATGCCCAAGTGTGAGAATGACCGGGTGGAG CTGCCCAGCCGTACCCTCTGCCAGGCCACCCGAGGCCCCTGTGCCATCGTGGAGAGGGAGCGGGGCTGGC CTGACTTCCTGCGCTGCACTCCTGACCGCTTCCCTGAAGGCTGCACGAATGAGGTGCAGAACATCAAGTT CAACAGTTCAGGCCAGTGCGAAGTGCCCTTGGTTCGGACAGACAACCCCAAGAGCTGGTACGAGGACGTG GAGGGCTGCGGCATCCAGTGCCAGAACCCGCTCTTCACAGAGGCTGAGCACCAGGACATGCACAGCTACA TCGCGGCCTTCGGGGCCGTCACGGGCCTCTGCACGCTCTTCACCCTGGCCACATTCGTGGCTGACTGGCG GAACTCGAATCGCTACCCTGCTGTTATTCTCTTCTACGTCAATGCGTGCTTCTTTGTGGGCAGCATTGGC TGGCTGGCCCAGTTCATGGATGGTGCCCGCCGAGAGATCGTCTGCCGTGCAGATGGCACCATGAGGCTTG GGGAGCCCACCTCCAATGAGACTCTGTCCTGCGTCATCATCTTTGTCATCGTGTACTACGCCCTGATGGC TGGTGTGGTTTGGTTTGTGGTCCTCACCTATGCCTGGCACACTTCCTTCAAAGCCCTGGGCACCACCTAC CAGCCTCTCTCGGGCAAGACCTCCTACTTCCACCTGCTCACCTGGTCACTCCCCTTTGTCCTCACTGTGG CAATCCTTGCTGTGGCGCAGGTGGATGGGGACTCTGTGAGTGGGATTTGTTTTGTGGGCTACAAGAACTA CCGATACCGTGCGGGCTTCGTGCTGGCCCCAATCGGCCTGGTGCTCATCGTGGGAGGCTACTTCCTCATC CGAGGAGTCATGACTCTGTTCTCCATCAAGAGCAACCACCCCGGGCTGCTGAGTGAGAAGGCTGCCAGCA AGATCAACGAGACCATGCTGCGCCTGGGCATTTTTGGCTTCCTGGCCTTTGGCTTTGTGCTCATTACCTT CAGCTGCCACTTCTACGACTTCTTCAACCAGGCTGAGTGGGAGCGCAGCTTCCGGGACTATGTGCTATGT CAGGCCAATGTGACCATCGGGCTGCCCACCAAGCAGCCCATCCCTGACTGTGAGATCAAGAATCGCCCGA GCCTTCTGGTGGAGAAGATCAACCTGTTTGCCATGTTTGGAACTGGCATCGCCATGAGCACCTGGGTCTG GACCAAGGCCACGCTGCTCATCTGGAGGCGTACCTGGTGCAGGTTGACTGGGCAGAGTGACGATGAGCCA AAGCGGATCAAGAAGAGCAAGATGATTGCCAAGGCCTTCTCTAAGCGGCACGAGCTCCTGCAGAACCCAG GCCAGGAGCTGTCCTTCAGCATGCACACTGTGTCCCACGACGGGCCCGTGGCGGGCTTGGCCTTTGACCT CAATGAGCCCTCAGCTGATGTCTCCTCTGCCTGGGCCCAGCATGTCACCAAGATGGTGGCTCGGAGAGGA GCCATACTGCCCCAGGATATTTCTGTCACCCCTGTGGCAACTCCAGTGCCCCCAGAGGAACAAGCCAACC TGTGGCTGGTTGAGGCAGAGATCTCCCCAGAGCTGCAGAAGCGCCTGGGCCGGAAGAAGAAGAGGAGGAA GAGGAAGAAGGAGGTGTGCCCGCTGGCGCCGCCCCCTGAGCTTCACCCCCCTGCCCCTGCCCCCAGTACC ATTCCTCGACTGCCTCAGCTGCCCCGGCAGAAATGCCTGGTGGCTGCAGGTGCCTGGGGAGCTGGGGACT CTTGCCGACAGGGAGCGTGGACCCTGGTCTCCAACCCATTCTGCCCAGAGCCCAGTCCCCCTCAGGATCC ATTTCTGCCCAGTGCACCGGCCCCCGTGGCATGGGCTCATGGCCGCCGACAGGGCCTGGGGCCTATTCAC TCCCGCACCAACCTGATGGACACAGAACTCATGGATGCAGACTCGGACTTCTGA Download Select all
CCDS ID	CCDS5811.1

Protein Information

Protein ID	NP_005622.1
Protein Name	Smoothened homolog (Drosophila)
Molecular Wt. (Da)	83322
Protein Sequence	>6608 MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPPLSHC GRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCA VYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQ CEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADW RNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVI VYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGD SVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINET MLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNR PSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKR HELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVT PVATPVPPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRL PQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGP IHSRTNLMDTELMDADSDF Download Select all
Length	787
Uniprot ID	O15528
Ensembl Protein ID	ENSP00000228606

Post-translational Modification Information (Source : HPRD)

No matching records could be found.

Enzyme Information

EC	1.5.3.16
Name	spermine oxidase PAOh1/SMO PAOh1 (ambiguous) AtPAO1 AtPAO4 SMO mSMO SMO(PAOh1) SMO/PAOh1 SMO5 mSMOmu
Class	Oxidoreductases; Acting on the CH-NH group of donors; With oxygen as acceptor
Sysname	spermidine:oxygen oxidoreductase (spermidine-forming)
Substrate	spermine [CPD:C00750]; O2 [CPD:C00007]; H2O
Product	spermidine [CPD:C00315]; 3-aminopropanal [CPD:C05665]; H2O2
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
5727	PTCH1	3200	NP_000255.2	in vivo	9811851

Pathway Information

Pathway Name	Pathway ID
Basal cell carcinoma	hsa05217
Hedgehog signaling pathway	hsa04340
Pathways in cancer	hsa05200
Proteoglycans in cancer	hsa05205

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd07451	66-196	CRD_SMO
cl02447	66-196	CRD_FZ superfamily
pfam01534	220-554	Frizzled
cl21587	220-554	7tm_2 superfamily
smart00063	70-181	FRI
pfam01392	70-180	Fz
cd07066	70-181	CRD_FZ
cd07449	70-176	CRD_FZ3
cd07448	70-176	CRD_FZ4
cd07463	66-175	CRD_FZ9
cd07447	117-178	CRD_Carboxypeptidase_Z
cd07461	117-176	CRD_FZ8
cd07444	95-175	CRD_SFRP5
cd07443	95-177	CRD_SFRP1
cd07456	70-181	CRD_FZ5_like
cd07457	68-177	CRD_FZ9_like
cd07442	66-169	CRD_SFRP4
cd07445	70-187	CRD_corin_1
cd07446	117-177	CRD_SFRP2
cd07458	118-176	CRD_FZ1_like
cd07453	125-176	CRD_crescent
cd07460	66-190	CRD_FZ5
cd07441	67-169	CRD_SFRP3
pfam00002	313-433	7tm_2
cd07465	117-175	CRD_FZ1
cd07452	118-177	CRD_sizzled
cd07466	117-189	CRD_FZ7

Ontology Information

HPRD ID	2902
Molecular Class	Integral membrane protein
Molecular Function	Protein serine/threonine kinase activity (GO:0004674)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO