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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19124482 | 2009 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry | Up-regulation | - | TGF-alpha expression in the normal-appearing rectal mucosa shows promise as an early, potentially modifiable biomarker of risk for colorectal cancer. TGF-alpha expression in the rectum was 51% higher in cases compared with controls. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. | Chromosome | 2 |
| Location | 2p13 |
| Start | 70447280 |
| End | 70554015 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 106736 |
| OMIM ID | 190170 |
| HGNC ID | HGNC:11765 |
| Unigene ID | Hs.170009 |
| Ensembl ID | ENSG00000163235 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001099691.2 |
|---|---|
| Exon | join(1..288,39104..39157,88283..88400,97528..97677, 100689..100798,103150..106736) | mRNA Sequence | Download Select all |
| Length | 4323 |
CDS Information
| Location | join(249..288,39104..39157,88283..88400,97528..97677, 100689..100798,103150..103157) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS46316.1 |
Protein Information
| Protein ID | XP_005264579.1 |
|---|---|
| Protein Name | transforming growth factor, alpha |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 0 |
| Uniprot ID | P11717 |
| Ensembl Protein ID | ENSP00000349437 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Palmitoylation | 153 |
| C | Palmitoylation | 154 |
| A | Proteolytic Cleavage | 39 |
| A | Proteolytic Cleavage | 89 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 102 | ADAM10 | 3723 | NP_001101.1 | in vitro | 12590602 |
| 1956 | EGFR | 579 | NP_005219.2 | in vitro | 12297049 |
| 1991 | ELANE | 554 | NP_001963.1 | in vitro | 15245434 |
| 2064 | ERBB2 | 1281 | NP_004439.2 | in vivo | 10918572 |
| 2066 | ERBB4 | 2767 | NP_005226.1 | in vivo | 10918572 |
| 6386 | SDCBP | 3741 | NP_005616.2 | in vitro;in vivo;yeast 2-hybrid | 10230395 |
| 6640 | SNTA1 | 3009 | NP_003089.1 | in vitro;yeast 2-hybrid | 10230395 |
| 9863 | MAGI2 | 16212 | NP_036433.2 | in vitro;yeast 2-hybrid | 15652357 |
| 64285 | RHBDF1 | 7027 | NP_071895.3 | in vitro;in vivo | 15965977 |
| 64689 | GORASP1 | 6038 | NP_114105.1 | in vivo;yeast 2-hybrid | 11739402 |
| 85409 | NKD2 | 8483 | NP_149111.1 | in vitro;in vivo;yeast 2-hybrid | 15064403 |
| 260425 | MAGI3 | 11290 | NP_001136254.1 | in vitro;in vivo;yeast 2-hybrid | 15652357 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| ErbB signaling pathway | hsa04012 |
| Glioma | hsa05214 |
| Non-small cell lung cancer | hsa05223 |
| Pancreatic cancer | hsa05212 |
| Pathways in cancer | hsa05200 |
| Prostate cancer | hsa05215 |
| Renal cell carcinoma | hsa05211 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| PHA02887 | 44-83 | PHA02887 |
| cl20100 | 44-83 | PHA02887 superfamily |
| PHA03099 | 47-121 | PHA03099 |
| cl20104 | 47-121 | PHA03099 superfamily |
Ontology Information
| HPRD ID | 899 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Growth factor binding (GO:0019838) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165); Apoptosis (GO:0006915) |
Drug Information
No matching records could be found.