Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| TIMP3 | 7078 | TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) | 22 | SFD; K222; K222TA2; HSMRK222 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17455256 | 2007 | Cell line : - Source : Department of Pathology of the Turku University Central Hospital. Sample Type : CRC tumor and normal tissue No. of Sample : 49 had Dukes A, 199 Dukes B, 42 Dukes C and 61 Dukes D tumors. Stage : - | Tissue microarray, Immunohistochemistry | Down-regulation | - | An important role for MMP-2 and TIMP-3 as prognostic markers for patients with colon and rectal cancer, respectively. The data of 351 CRC patients who had undergone bowel resection in 1981-1990 were included in the study. |
| 23037807 | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Down-regulation | - | TIMP3 suppressed in vivo tumor growth and that liver metastasis was significantly reduced by TIMP3 transduction. TIMP3 may be a potential molecular tool for colon cancer biological therapy. mRNA and protein levels of tissue inhibitor of metalloproteinase-3 (TIMP3) were decreased significantly in colorectal cancer tissue when compared with normal mucosa, suggesting that decrease of TIMP3 expression was correlated with malignant behavior of colorectal cancer. |
| 17657847 | 2007 | Cell line : - Source : Tumor Hospital of Harbin Medical University. Sample Type : - No. of Sample : 80 patients and 20 normal colonic mucosa. Stage : Duke Stage A-D | SABC immunohistochemistry | Down-regulation | - | Expression of BAG1 and TIMP3 was strongly associated with colon carcinoma differentiation, Duke's staging, lymph node metastasis and survival rate. Over-expression of BAG1 or attenuated expression of TIMP3 may play an important role in genesis and development of colon carcinoma. |
| 18437011 | 2008 | Cell line : - Source : Colorectal cancer clinic of Asan Medical Center. Sample Type : CRC tumor and normal tissue No. of Sample : 25 colorectal cancer patients with a family history of colorectal cancer and enrolled 30 patients with sporadic colorectal cancers and no family history of colon tumors Stage : - | Methylation specific PCR | Methylation | - | CpG island methylation of tumor suppressor genes may play a role in colorectal carcinogenesis, the genes involved may be different between tumors of patients with and without a family history of colorectal cancer. |
| 20836393 | 2010 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | DNA bisulfite modification, PCR with biotinylated primers, agarose gel electrophoresis and pyrosequencing | Methylation | - | The level of hMLH1 and TIMP3 methylation and CIMP status can be correlated with the local tumour invasion. |
| 22132162 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 12 pair of CRC and normal tissue sample Stage : - | Bisulfite-pyrosequencing validation and methylated CpG island amplification microarrays | Methylation | - | Most DNA methylation differences between primary CRCs and matched liver metastasis are due to random variation and an increase in DNA methylation density rather than de-novo inactivation and silencing. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008] | Chromosome | 22 |
| Location | 22q12.3 |
| Start | 32800816 |
| End | 32863041 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 62226 |
| OMIM ID | 188826 |
| HGNC ID | HGNC:11822 |
| Unigene ID | Hs.644633 |
| Ensembl ID | ENSG00000100234 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_000362.4 |
|---|---|
| Exon | join(1..1307,48637..48719,56434..56545,57202..57323, 58365..62226) | mRNA Sequence | Download Select all |
| Length | 5496 |
CDS Information
| Location | join(1187..1307,48637..48719,56434..56545,57202..57323, 58365..58562) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS13911.1 |
Protein Information
| Protein ID | NP_000353.1 |
|---|---|
| Protein Name | TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) |
| Molecular Wt. (Da) | 21690 |
| Protein Sequence | Download Select all |
| Length | 211 |
| Uniprot ID | P11532 |
| Ensembl Protein ID | ENSP00000354464 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4313 | MMP2 | 386 | NP_004521.1 | in vitro | 778 228 910 196 161 |
| 4314 | MMP3 | 1703 | NP_002413.1 | in vitro;in vivo | 11827795 |
| 4318 | MMP9 | 387 | NP_004985.2 | in vitro;in vivo | 11827795 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MicroRNAs in cancer | hsa05206 |
| Proteoglycans in cancer | hsa05205 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03585 | 24-200 | NTR_TIMP |
| cl02512 | 24-200 | NTR_like superfamily |
| smart00206 | 24-194 | NTR |
| pfam00965 | 22-194 | TIMP |
| cd03577 | 24-139 | NTR_TIMP_like |
| cd03523 | 34-136 | NTR_like |
Ontology Information
| HPRD ID | 9121 |
|---|---|
| Molecular Class | Extracellular matrix protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.