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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
TRIM29 23650 tripartite motif containing 29  11ATDC, FLJ36085 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24078150   2013Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 203 cases of primary colorectal cancer paired with non-cancerous tissues.

Stage : -

real time RT-PCR, Tissue microarray and immunohistochemistryUp-regulation-TRIM29 may serve as a novel biomarker for tumor recurrence and survival for colorectal cancer patients.

TRIM29 expression was much higher in colorectal cancer tissues and significantly associated with the depth of tumor invasion, lymph node metastasis, distant metastasis, histological differentiation, vascular invasion, ki-67 index, and advanced tumor stage


Gene Details



Chromosome 11 - NC_000011.10(120111286..120185423, complement)

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Gene Type protein coding
Gene Family Tripartite motif containing / Tripartite motif containing
Description The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype.  
Chromosome 11
Location 11q23.3
Start 120111286  
End 120185423  
Strand -  
Gene Sequence

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Length 74138  
OMIM ID 610658   
HGNC ID HGNC:17274   
Unigene ID Hs.504115   
Ensembl ID ENSG00000137699   
PharmGKB ID -   

mRNA Information


mRNA ID XM_011542731.1
Exon join(1..174,47279..48196,56929..57024,57855..58088, 59535..59733,62369..62470,64759..64851,67103..67201, 68364..68465,70010..70086,72948..74138)  
mRNA Sequence

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Length 3037  



CDS Information


   
Location join(47393..48196,56929..57024,57855..58088,59535..59733, 62369..62470,64759..64851,67103..67201,70010..70086, 72948..73010)
CDS Sequence

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CCDS ID CCDS8428.1



Protein Information


      
Protein IDNP_036233.2
Protein Nametripartite motif containing 29
Molecular Wt. (Da)65704
Protein Sequence

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Length 588  
Uniprot IDP10721
Ensembl Protein ID ENSP00000288135  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation21
SPhosphorylation21
SPhosphorylation23
SPhosphorylation23
SPhosphorylation104
SPhosphorylation104
TPhosphorylation476
TPhosphorylation476
SPhosphorylation489
SPhosphorylation489
SPhosphorylation58
SPhosphorylation58
YPhosphorylation93
YPhosphorylation93
SPhosphorylation488
SPhosphorylation488
SPhosphorylation7
SPhosphorylation12
SPhosphorylation7
SPhosphorylation12
SPhosphorylation9
SPhosphorylation9
SPhosphorylation13
SPhosphorylation13
SPhosphorylation26
SPhosphorylation28
TPhosphorylation33
SPhosphorylation26
SPhosphorylation28
TPhosphorylation33
SPhosphorylation95
SPhosphorylation95
YPhosphorylation474
YPhosphorylation474

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                     
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
373TRIM233449NP_001647.1yeast 2-hybrid11331580   
3094HINT13204NP_005331.1in vitro7644499   
4093SMAD94484BAA21128.1yeast 2-hybrid15231748   
5578PRKCA1498NP_002728.1in vitro;yeast 2-hybrid7644499   
7431VIM1899NP_003371.2in vitro;yeast 2-hybrid7644499   
9832JAKMIP211090NP_055605.2yeast 2-hybrid16189514   
11043MID22191NP_036348.2yeast 2-hybrid11331580   
80321CEP7016779NP_077817.2yeast 2-hybrid16189514   
81559TRIM117429NP_660215.1yeast 2-hybrid11331580   
84445LZTS214341NP_115805.1yeast 2-hybrid16189514   
85302FBF110948NP_001074011.1yeast 2-hybrid16189514   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00021223-260  BBOX
cl00034223-260  BBOX superfamily
smart00336220-260  BBOX
pfam00643220-260  zf-B_box
pfam03938272-355  OmpH
cl21485272-355  OmpH superfamily
smart00935273-355  OmpH
pfam05615271-366  THOC7
cl09577271-366  THOC7 superfamily
pfam00435287-366  Spectrin
cl02488287-366  SPEC superfamily
pfam13868273-362  Trichoplein
TIGR02168276-366  SMC_prok_B
pfam07888271-372  CALCOCO1
COG1579271-379  COG1579
TIGR02168271-367  SMC_prok_B
COG0419271-367  SbcC


Ontology Information


   
HPRD ID1970
Molecular ClassTranscription regulatory protein
Molecular FunctionProtease inhibitor activity (GO:0030414)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO