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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25197375 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 125 Stage : - | - | Down-regulation | - | Low expression of UPKIa was a promising predictor for poor outcome of colorectal cancer patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Tetraspanins |
| Description | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] | Chromosome | 19 |
| Location | 19q13.1 |
| Start | 36157418 |
| End | 36169387 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 11970 |
| OMIM ID | 611557 |
| HGNC ID | HGNC:12577 |
| Unigene ID | Hs.159309 |
| Ensembl ID | ENSG00000105668 |
| PharmGKB ID | PA37209 |
Protein Information
| Protein ID | NP_001268372.1 |
|---|---|
| Protein Name | uroplakin 1A |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 258 |
| Uniprot ID | Q9ULC4 |
| Ensembl Protein ID | ENSP00000360365 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7379 | UPK2 | 10295 | NP_006751.1 | in vitro;in vivo | 12475947 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03156 | 112-230 | uroplakin_I_like_LEL |
| cl02781 | 112-230 | tetraspanin_LEL superfamily |
| cd03127 | 115-206 | tetraspanin_LEL |
| cd03155 | 112-220 | CD151_like_LEL |
| cd03165 | 139-220 | NET-5_like_LEL |
| cd03163 | 147-220 | TM4SF8_like_LEL |
| pfam00335 | 24-255 | Tetraspannin |
Ontology Information
| HPRD ID | 11043 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.