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Pathway Name: AGE-RAGE signaling pathway in diabetic complications

Pathway Information (Click on respective Gene ID or Gene Symbol for more information)


Pathway ID Gene ID Gene Symbol Gene Name
hsa04933 10000 AKT3 v-akt murine thymoma viral oncogene homolog 3
hsa04933 1019 CDK4 cyclin-dependent kinase 4
hsa04933 1027 CDKN1B Cyclin-dependent kinase inhibitor 1B (p27, Kip1)
hsa04933 1277 COL1A1 collagen, type I, alpha 1
hsa04933 1278 COL1A2 collagen, type I, alpha 2
hsa04933 1282 COL4A1 collagen, type IV, alpha 1
hsa04933 1284 COL4A2 collagen, type IV, alpha 2
hsa04933 1287 COL4A5 collagen, type IV, alpha 5
hsa04933 1288 COL4A6 collagen, type IV, alpha 6
hsa04933 1432 MAPK14 mitogen-activated protein kinase 14
hsa04933 1729 DIAPH1 diaphanous-related formin 1
hsa04933 185 AGTR1 angiotensin II receptor, type 1
hsa04933 1958 EGR1 early growth response 1
hsa04933 207 AKT1 v-akt murine thymoma viral oncogene homolog 1
hsa04933 208 AKT2 V-akt murine thymoma viral oncogene homolog 2
hsa04933 2308 FOXO1 forkhead box O1
hsa04933 2335 FN1 fibronectin 1
hsa04933 23533 PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
hsa04933 27035 NOX1 NADPH oxidase 1
hsa04933 3265 HRAS Harvey rat sarcoma viral oncogene homolog
hsa04933 3383 ICAM1 Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
hsa04933 3552 IL1A Interleukin 1, alpha
hsa04933 3553 IL1B interleukin 1, beta
hsa04933 3569 IL6 interleukin 6
hsa04933 3576 CXCL8 chemokine (C-X-C motif) ligand 8
hsa04933 3717 JAK2 Janus kinase 2
hsa04933 3725 JUN Jun oncogene
hsa04933 3845 KRAS V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
hsa04933 4087 SMAD2 SMAD family member 2
hsa04933 4088 SMAD3 SMAD family member 3
hsa04933 4089 SMAD4 SMAD family member 4
hsa04933 4313 MMP2 matrix metallopeptidase 2
hsa04933 4790 NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa04933 4846 NOS3 Nitric oxide synthase 3 (endothelial cell)
hsa04933 4893 NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
hsa04933 5054 SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
hsa04933 51196 PLCE1 phospholipase C, epsilon 1
hsa04933 5290 PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
hsa04933 5291 PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
hsa04933 5293 PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
hsa04933 5294 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
hsa04933 5295 PIK3R1 Phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)
hsa04933 5296 PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
hsa04933 5578 PRKCA Protein kinase C, alpha
hsa04933 5594 MAPK1 mitogen-activated protein kinase 1
hsa04933 5595 MAPK3 mitogen-activated protein kinase 3
hsa04933 5599 MAPK8 mitogen-activated protein kinase 8
hsa04933 5600 MAPK11 mitogen-activated protein kinase 11
hsa04933 5601 MAPK9 mitogen-activated protein kinase 9
hsa04933 581 BAX BCL2-associated X protein
hsa04933 5879 RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
hsa04933 595 CCND1 Cyclin D1
hsa04933 596 BCL2 B-cell CLL/lymphoma 2
hsa04933 5970 RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
hsa04933 6347 CCL2 chemokine (C-C motif) ligand 2
hsa04933 6772 STAT1 signal transducer and activator of transcription 1, 91kDa
hsa04933 6774 STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
hsa04933 6776 STAT5A signal transducer and activator of transcription 5A
hsa04933 6777 STAT5B signal transducer and activator of transcription 5B
hsa04933 7040 TGFB1 transforming growth factor, beta 1
hsa04933 7042 TGFB2 transforming growth factor, beta 2
hsa04933 7043 TGFB3 transforming growth factor, beta 3
hsa04933 7046 TGFBR1 transforming growth factor, beta receptor 1
hsa04933 7048 TGFBR2 Transforming growth factor, beta receptor II (70/80kDa)
hsa04933 7124 TNF Tumor necrosis factor (TNF superfamily, member 2)
hsa04933 7412 VCAM1 vascular cell adhesion molecule 1
hsa04933 7422 VEGFA Vascular endothelial growth factor A
hsa04933 7423 VEGFB vascular endothelial growth factor B
hsa04933 7424 VEGFC vascular endothelial growth factor C
hsa04933 836 CASP3 caspase 3, apoptosis-related cysteine peptidase
hsa04933 8503 PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
hsa04933 998 CDC42 cell division cycle 42