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Pathway Name: PI3K-Akt signaling pathway

Pathway Information (Click on respective Gene ID or Gene Symbol for more information)


Pathway ID Gene ID Gene Symbol Gene Name
hsa04151 10000 AKT3 v-akt murine thymoma viral oncogene homolog 3
hsa04151 10018 BCL2L11 BCL2-like 11 (apoptosis facilitator)
hsa04151 10161 LPAR6 lysophosphatidic acid receptor 6
hsa04151 1017 CDK2 Cyclin-dependent kinase 2
hsa04151 1019 CDK4 cyclin-dependent kinase 4
hsa04151 1021 CDK6 Cyclin-dependent kinase 6
hsa04151 1026 CDKN1A Cyclin-dependent kinase inhibitor 1A (p21, Cip1)
hsa04151 1027 CDKN1B Cyclin-dependent kinase inhibitor 1B (p27, Kip1)
hsa04151 10319 LAMC3 laminin, gamma 3
hsa04151 10681 GNB5 guanine nucleotide binding protein (G protein), beta 5
hsa04151 1277 COL1A1 collagen, type I, alpha 1
hsa04151 1278 COL1A2 collagen, type I, alpha 2
hsa04151 1282 COL4A1 collagen, type IV, alpha 1
hsa04151 1284 COL4A2 collagen, type IV, alpha 2
hsa04151 1287 COL4A5 collagen, type IV, alpha 5
hsa04151 1288 COL4A6 collagen, type IV, alpha 6
hsa04151 1293 COL6A3 collagen, type VI, alpha 3
hsa04151 1386 ATF2 activating transcription factor 2
hsa04151 1436 CSF1R colony stimulating factor 1 receptor
hsa04151 1441 CSF3R colony stimulating factor 3 receptor (granulocyte)
hsa04151 1902 LPAR1 Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2
hsa04151 1942 EFNA1 ephrin-A1
hsa04151 1950 EGF epidermal growth factor
hsa04151 1956 EGFR Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
hsa04151 1969 EPHA2 EPH receptor A2
hsa04151 1978 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
hsa04151 2056 EPO erythropoietin
hsa04151 2057 EPOR erythropoietin receptor
hsa04151 207 AKT1 v-akt murine thymoma viral oncogene homolog 1
hsa04151 208 AKT2 V-akt murine thymoma viral oncogene homolog 2
hsa04151 2246 FGF1 fibroblast growth factor 1 (acidic)
hsa04151 2247 FGF2 fibroblast growth factor 2 (basic)
hsa04151 2248 FGF3 fibroblast growth factor 3
hsa04151 2250 FGF5 fibroblast growth factor 5
hsa04151 2253 FGF8 fibroblast growth factor 8 (androgen-induced)
hsa04151 2254 FGF9 fibroblast growth factor 9
hsa04151 2255 FGF10 fibroblast growth factor 10
hsa04151 2257 FGF12 fibroblast growth factor 12
hsa04151 2260 FGFR1 fibroblast growth factor receptor 1
hsa04151 2261 FGFR3 fibroblast growth factor receptor 3
hsa04151 2263 FGFR2 fibroblast growth factor receptor 2
hsa04151 2264 FGFR4 fibroblast growth factor receptor 4
hsa04151 22798 LAMB4 laminin, beta 4
hsa04151 23035 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
hsa04151 2309 FOXO3 Forkhead box O3
hsa04151 2321 FLT1 fms-related tyrosine kinase 1
hsa04151 23239 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
hsa04151 2324 FLT4 fms-related tyrosine kinase 4
hsa04151 2335 FN1 fibronectin 1
hsa04151 23533 PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
hsa04151 2475 MTOR mechanistic target of rapamycin (serine/threonine kinase)
hsa04151 2688 GH1 Growth hormone 1
hsa04151 2690 GHR growth hormone receptor
hsa04151 284 ANGPT1 angiopoietin 1
hsa04151 284217 LAMA1 laminin, alpha 1
hsa04151 285 ANGPT2 angiopoietin 2
hsa04151 2885 GRB2 Growth factor receptor-bound protein 2
hsa04151 2932 GSK3B glycogen synthase kinase 3 beta
hsa04151 3082 HGF hepatocyte growth factor (hepapoietin A; scatter factor)
hsa04151 3265 HRAS Harvey rat sarcoma viral oncogene homolog
hsa04151 3320 HSP90AA1 Heat shock protein 90kDa alpha (cytosolic), class A member 1
hsa04151 3326 HSP90AB1 Heat shock protein 90kDa alpha (cytosolic), class B member 1
hsa04151 3439 IFNA1 Interferon, alpha 1
hsa04151 3454 IFNAR1 interferon (alpha, beta and omega) receptor 1
hsa04151 3479 IGF1 Insulin-like growth factor 1 (somatomedin C)
hsa04151 3480 IGF1R Insulin-like growth factor 1 receptor
hsa04151 3551 IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
hsa04151 3558 IL2 Interleukin 2
hsa04151 356 FASLG Fas ligand (TNF superfamily, member 6)
hsa04151 3565 IL4 Interleukin 4
hsa04151 3566 IL4R interleukin 4 receptor
hsa04151 3569 IL6 interleukin 6
hsa04151 3643 INSR insulin receptor
hsa04151 3655 ITGA6 integrin subunit alpha 6
hsa04151 3667 IRS1 insulin receptor substrate 1
hsa04151 3672 ITGA1 integrin, alpha 1
hsa04151 3673 ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
hsa04151 3675 ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
hsa04151 3676 ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
hsa04151 3678 ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
hsa04151 3679 ITGA7 integrin, alpha 7
hsa04151 3685 ITGAV integrin, alpha V
hsa04151 3688 ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
hsa04151 3690 ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
hsa04151 3691 ITGB4 Integrin, beta 4
hsa04151 3693 ITGB5 integrin, beta 5
hsa04151 3695 ITGB7 integrin, beta 7
hsa04151 3716 JAK1 Janus kinase 1
hsa04151 3717 JAK2 Janus kinase 2
hsa04151 3718 JAK3 Janus kinase 3
hsa04151 3791 KDR kinase insert domain receptor (a type III receptor tyrosine kinase)
hsa04151 3815 KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
hsa04151 3845 KRAS V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
hsa04151 3908 LAMA2 laminin, alpha 2
hsa04151 3909 LAMA3 laminin, alpha 3
hsa04151 3910 LAMA4 laminin, alpha 4
hsa04151 3911 LAMA5 Laminin, alpha 5
hsa04151 3912 LAMB1 laminin, beta 1
hsa04151 3913 LAMB2 Laminin, beta 2 (laminin S)
hsa04151 3914 LAMB3 Laminin, beta 3
hsa04151 3915 LAMC1 laminin, gamma 1 (formerly LAMB2)
hsa04151 3918 LAMC2 Laminin, gamma 2
hsa04151 4170 MCL1 myeloid cell leukemia 1
hsa04151 4193 MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
hsa04151 4233 MET MET proto-oncogene, receptor tyrosine kinase
hsa04151 4602 MYB v-myb avian myeloblastosis viral oncogene homolog
hsa04151 4609 MYC v-myc avian myelocytomatosis viral oncogene homolog
hsa04151 4790 NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
hsa04151 4803 NGF nerve growth factor (beta polypeptide)
hsa04151 4804 NGFR nerve growth factor receptor
hsa04151 4846 NOS3 Nitric oxide synthase 3 (endothelial cell)
hsa04151 4893 NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
hsa04151 5155 PDGFB platelet-derived growth factor beta polypeptide
hsa04151 5156 PDGFRA platelet-derived growth factor receptor, alpha polypeptide
hsa04151 5159 PDGFRB platelet-derived growth factor receptor, beta polypeptide
hsa04151 5170 PDPK1 3-phosphoinositide dependent protein kinase-1
hsa04151 5228 PGF placental growth factor
hsa04151 5290 PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
hsa04151 5291 PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
hsa04151 5293 PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
hsa04151 5294 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
hsa04151 5295 PIK3R1 Phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)
hsa04151 5296 PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
hsa04151 5519 PPP2R1B protein phosphatase 2, regulatory subunit A, beta
hsa04151 5520 PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
hsa04151 5522 PPP2R2C Protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform
hsa04151 5562 PRKAA1 Protein kinase, AMP-activated, alpha 1 catalytic subunit
hsa04151 5563 PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
hsa04151 5578 PRKCA Protein kinase C, alpha
hsa04151 5585 PKN1 Protein kinase N1
hsa04151 5594 MAPK1 mitogen-activated protein kinase 1
hsa04151 5595 MAPK3 mitogen-activated protein kinase 3
hsa04151 5604 MAP2K1 mitogen-activated protein kinase kinase 1
hsa04151 5617 PRL prolactin
hsa04151 5728 PTEN Phosphatase and tensin homolog (mutated in multiple advanced cancers 1)
hsa04151 5747 PTK2 protein tyrosine kinase 2
hsa04151 5879 RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
hsa04151 5894 RAF1 V-raf-1 murine leukemia viral oncogene homolog 1
hsa04151 59345 GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4
hsa04151 595 CCND1 Cyclin D1
hsa04151 596 BCL2 B-cell CLL/lymphoma 2
hsa04151 5970 RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
hsa04151 598 BCL2L1 BCL2-like 1
hsa04151 6198 RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
hsa04151 6199 RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
hsa04151 6256 RXRA retinoid X receptor, alpha
hsa04151 6446 SGK1 serum/glucocorticoid regulated kinase 1
hsa04151 64764 CREB3L2 cAMP responsive element binding protein 3-like 2
hsa04151 6654 SOS1 son of sevenless homolog 1 (Drosophila)
hsa04151 6696 SPP1 secreted phosphoprotein 1
hsa04151 672 BRCA1 breast cancer 1, early onset
hsa04151 6794 STK11 Serine/threonine kinase 11
hsa04151 6850 SYK spleen tyrosine kinase
hsa04151 7057 THBS1 thrombospondin 1
hsa04151 7060 THBS4 thrombospondin 4
hsa04151 7097 TLR2 Toll-like receptor 2
hsa04151 7099 TLR4 Toll-like receptor 4
hsa04151 7148 TNXB Tenascin XB
hsa04151 7157 TP53 tumor protein p53
hsa04151 7184 HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
hsa04151 7248 TSC1 Tuberous sclerosis 1
hsa04151 7249 TSC2 tuberous sclerosis 2
hsa04151 7422 VEGFA Vascular endothelial growth factor A
hsa04151 7423 VEGFB vascular endothelial growth factor B
hsa04151 7424 VEGFC vascular endothelial growth factor C
hsa04151 7448 VTN vitronectin
hsa04151 7450 VWF Von Willebrand factor
hsa04151 7531 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
hsa04151 8074 FGF23 fibroblast growth factor 23
hsa04151 842 CASP9 caspase 9, apoptosis-related cysteine peptidase
hsa04151 8503 PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
hsa04151 894 CCND2 cyclin D2
hsa04151 896 CCND3 cyclin D3
hsa04151 898 CCNE1 cyclin E1
hsa04151 9134 CCNE2 cyclin E2
hsa04151 9170 EDG4 Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4
hsa04151 9180 OSMR oncostatin M receptor
hsa04151 9965 FGF19 fibroblast growth factor 19